Situated at the junction of large networks of printers, engravers, and poets linking the city to Italy as well as to Germany, Lyons emerged in the first half of the 1500s as the melting pot for philological, iconographical, symbolical, and political experiments that decisively innervated the reading of the Bible. Jean de Vauzelles (c. 1495-1563), the central figure of this study, incarnated precisely the conciliation between religion and humanism that was attempted there at that time. Seconding Marguerite de Navarre’s desire to have the Scriptures rendered into graceful French, he translated Aretino’s adaptations of the Bible and Ottmar Nachtigall’s Hystoire evangelique for her. The collection of texts that he dedicated to Marguerite as well as to Louise de Savoie provides evidence about religious life at the French court. At the same time, Vauzelles particapted with the Dominican Sante Pagnini in the revival of Hebrew studies in Lyons and in the foundation of the famous Aumône générale. Beyond the figure of Vauzelles, this volume sheds light on the vitality in Lyons of an open and active Catholicism porous to literary fashions and humanistic and artistic contributions, sensitive to the municipal need for works of charity and to contemporary preoccupations regarding the circulation of the Scriptures in French, and desirous to develop an incarnate piety.